Understanding your unique genetic response to different foods, along with how you metabolise vitamins, minerals, glucose, and fats, can pave the way for vitality, better immune system health, balanced hormonal health, reduced anxiety, improved digestion, and healthy skin.
Nutrigenomics is a growing scientific field in health and nutrition that offers us powerful insights to optimise wellbeing and reduce the risk of disease.
What is Nutrigenomics?
Nutrigenomics specifically focuses on how changes in our DNA sequence, also known as genetic variants, can influence our response to food and nutrients, along with how diet can affect gene expression.
Genetic variants can influence food sensitivities, blood pressure, glucose and lipid metabolism, cholesterol levels, antioxidant levels, vitamins and minerals.
They can also provide insights into our ability to manage stress, our susceptibility for anxiety, and our sleep health.
Understanding your genetic susceptibilities can be a useful first step to personalised nutrition and healthcare, which can help to prevent or manage chronic conditions.
Why Whole Genome Sequencing?
While most genetic tests on the market only analyse a small number of changes, this test uses Whole Genome Sequencing to sequence your entire genome.
Whole Genome Sequencing is the most comprehensive genetic test available, ensuring that no genetic information is missed.
It is also future-proof and better for the environment – as our understanding of the significance of specific genetic variation evolves, you won’t need to pay for another costly genetic test, your whole genome sequence can be simply reanalysed.
My genetic testing programme
£889
✓ Whole Genome Sequencing, worth £599
✓ Secure storage of your genomic data
✓ Genomic data analysis, and full reports of the findings
✓ Genomic counselling appointment, 45 minutes
✓ Comprehensive Nutritional Therapy consultation, 1 hour 15 minutes
✓ Evidence-based personalised diet and lifestyle plan tailored to your health goals and genomic test results
✓ Recommendations for high-quality supplements and further testing
✓ Educational materials
Book a free 30 minute consultation to find out more about genetic testing and working with me.
What genes are currently included within the analysis?
Dietary Sensitivities and Responses
Caffeine metabolism: AHR, CYP1A2, ADORA2A
Lactose tolerance: MCM6
Histamine tolerance: AOC1
Bitter taste perception: TAS2R38
Alcohol sensitivity: ALDH2, ADH1B
Celiac disease or gluten sensitivity: HLA-DQA1, HLA-DQB1
Salt sensitivity hypertension: AGT, ACE
Vitamin D metabolism: GC, CYP2R1
Vitamin D response: VDR
Vitamin A metabolism: BCO1
Vitamin B12 levels: FUT2
Vitamin C levels: SLC23A1
Vitamin K levels: VKORC1
Magnesium levels: TRPM6
Calcium levels: CASR
Methylation and Detoxification
Folate cycle: MTHFD1, MTHFR, SHMT1
Methionine cycle: MAT1A, MTR, MTRR, PEMT, BHMT
Neurotransmitters: COMT
Oxidative stress: GPX1, GSTP1, NQO1
Metabolism and Energy Regulation
Fat storage: FTO
Insulin and glucose levels: TCF7L2, ADIPOQ, ADCY5
Oxidative stress: G6PD
Poly-unsaturated fatty acid metabolism: FADS1, FADS2
Lifestyle: Sleep and Fitness
GABA levels: GAD1
Sleep quality: GRIA3
Insomnia susceptibility: MTNR1B
Muscle performance: ACTN3
Speed/Strength or Endurance Sports: GALNTL6
Oxygen transport: EPOR
Vasodilation and Blood Pressure: ACE, NOS3
Mitochondrial Health: SOD2
Cholesterol and Lp(a)
Familial hypercholesterolaemia: LDLR, APOB, PCSK9, APOE
Cardiovascular disease risk: Polygenic risk score based
High Lp(a): Polygenic risk score based
Pharmacogenomics
Including: SLCO1B1, CYP2C9, CYP2C19, G6PD, ACBG2
This list will continue to increase as scientific evidence for other genetic variants grows.
Dr Anna Sanniti 